Dr. Nel's chief research interests are: (i) Nanomedicine and Nanobiology, including nanomaterial therapeutic devices and the study of nanomaterial properties that lead to biocompatible and biohazardous interactions in humans and the environment; (ii) The role of air pollutants in asthma, with particular emphasis on the role of ultrafine particle-induced oxidative stress in the generation of airway inflammation and asthma. The research is funded by personal RO1 grants from the NIH, the NIAID-funded Asthma and Immunology Disease Clinical Research Center, an EPA STAR award, a $24 million NSF award for a NSF Science Engineering Center. Dr Nel is Director of the UC Center for the Environmental Impact of Nanotechnology (CEIN), Director of the UCLA Asthma and Immunology Disease Center, Co-Director of the Southern California Particle Center, and Co-Director of the UCLA Nanomachine Center. The Nanomachine Center (four co-PI?s) develops and utilizes smart nanoparticle delivery systems that can target and control drug release at cancer and disease sites. The mission of the multi-campus UC CEIN is to develop an early warning system for nanomaterial hazards and safe design, particularly as it relates to interactions with biological systems and ecological life forms.
Wang, X., Xia, T.,Duch, M.C., Ji, X., Zhang, H., Li, R., Sun, B.,Lin, S., Meng, H.,Liao,Y., Wang, M., Song, T.,Yang, Y., Hersam, M.C., and Nel, A.E.Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury. Nano Lett 12(6):3050-61 (2012).
Zhang, H., Ji, Z., Xia, T., Meng, H., Low-Kam, C., Liu, R., Pokhrel, S., Lin, S., Wang, X., Liao, Y.P., Wang, M., Li, L., Rallo. R., Damoiseaux, R., Telesca, D., Mädler, L., Cohen, Y., Zink, J.I., Nel, A.E. Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation. ACS Nano 6(5):4349-68 (2012).
George, S., Lin, S., Ji, Z., Thomas, C.R., Li, L., Mecklenburg, M., Meng, H., Wang, X., Zhang,H., Xia, T., Hohman, J.N., Lin, S., Zink, J.I., Weiss, P.S., Nel, A.E. Surface Defects on Plate-Shaped Silver Nanoparticles Contribute to its Hazard Potential in a Fish Gill Cell Line and Zebra Fish Embryos. ACS Nano. 6(5):3745-59 (2012).
Nel, A.E., Xia, T., Meng, H., Wang, X., Lin, S., Ji, Z., and Zhang, H. Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High Throughput Screening. Acc. Chem. Res. Epub ahead of print (2012).
Lin, S., Zhao, Y., Xia, T., Meng, H., Ji, Z., Liu, R., George, S., Xiong, S., Wang, X., Zhang, H., Pokhrel, S., Lutz Mädler, L., Damoiseaux, R., Lin, S., and Nel, A.E.High Content Screening in Zebrafish Speeds up Hazard Ranking of Transition Metal Oxide Nanoparticles. ACS Nano 5 (9):7284-95 (2011).
Nanobiology, The role of air pollutants in asthma with particular emphasis on the role of ultrafine particle-induced oxidative stress in the generation of airway inflammation and asthma