Acetoin, diacetyl, and 2,3-pentanedione are artificial butter flavorings used in the food and flavoring industry, including in making microwave popcorn. Occupational exposures to their vapors are associated with various upper and lower respiratory problems, such as bronchiolitis obliterans. Therefore, air monitoring of these ketone vapors is critical to assess worker health. In this research, dynamic (active) and passive (diffusive) air sampling methods were developed to measure the concentration of these ketone vapors accurately and precisely under a wide range of environmental conditions, such as at different concentrations, temperatures, and relative humidities. The sampling tubes and badges were produced using Tenax TA coated with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA). The presentation will show the scientific approach to solve the various problems involved in developing accurate and precise sampling and analytical methods based on chemisorption, surface chemistry to produce a more suitable derivative for analysis than the original exposing agent.